diff --git a/migration/multifd.c b/migration/multifd.c
index 01f427d8ed..add6f86175 100644
--- a/migration/multifd.c
+++ b/migration/multifd.c
@@ -50,6 +50,10 @@ typedef struct {
 
 struct {
     MultiFDSendParams *params;
+
+    /* multifd_send() body is not thread safe, needs serialization */
+    QemuMutex multifd_send_mutex;
+
     /*
      * Global number of generated multifd packets.
      *
@@ -339,6 +343,8 @@ bool multifd_send(MultiFDSendData **send_data)
         return false;
     }
 
+    QEMU_LOCK_GUARD(&multifd_send_state->multifd_send_mutex);
+
     /* We wait here, until at least one channel is ready */
     qemu_sem_wait(&multifd_send_state->channels_ready);
 
@@ -507,6 +513,7 @@ static void multifd_send_cleanup_state(void)
     socket_cleanup_outgoing_migration();
     qemu_sem_destroy(&multifd_send_state->channels_created);
     qemu_sem_destroy(&multifd_send_state->channels_ready);
+    qemu_mutex_destroy(&multifd_send_state->multifd_send_mutex);
     g_free(multifd_send_state->params);
     multifd_send_state->params = NULL;
     g_free(multifd_send_state);
@@ -887,6 +894,7 @@ bool multifd_send_setup(void)
     thread_count = migrate_multifd_channels();
     multifd_send_state = g_malloc0(sizeof(*multifd_send_state));
     multifd_send_state->params = g_new0(MultiFDSendParams, thread_count);
+    qemu_mutex_init(&multifd_send_state->multifd_send_mutex);
     qemu_sem_init(&multifd_send_state->channels_created, 0);
     qemu_sem_init(&multifd_send_state->channels_ready, 0);
     qatomic_set(&multifd_send_state->exiting, 0);