diff --git a/accel/tcg/translate-all.c b/accel/tcg/translate-all.c
index 453eb20ec9..d56ca13cdd 100644
--- a/accel/tcg/translate-all.c
+++ b/accel/tcg/translate-all.c
@@ -633,9 +633,10 @@ void cpu_io_recompile(CPUState *cpu, uintptr_t retaddr)
      * Exit the loop and potentially generate a new TB executing the
      * just the I/O insns. We also limit instrumentation to memory
      * operations only (which execute after completion) so we don't
-     * double instrument the instruction.
+     * double instrument the instruction. Also don't let an IRQ sneak
+     * in before we execute it.
      */
-    cpu->cflags_next_tb = curr_cflags(cpu) | CF_MEMI_ONLY | n;
+    cpu->cflags_next_tb = curr_cflags(cpu) | CF_MEMI_ONLY | CF_NOIRQ | n;
 
     if (qemu_loglevel_mask(CPU_LOG_EXEC)) {
         vaddr pc = cpu->cc->get_pc(cpu);